2024 Klf4 atherosclerosis

Klf4 atherosclerosis

Author: bhdm

August undefined, 2024

WebAug 1, 2024 · However, since the clinical consequences of atherosclerosis typically occur well after our reproductive years, we sought to identify beneficial KLF4-dependent SMC functions that were likely to be evolutionarily conserved. We tested the hypothesis that … WebJun 29, 2024 · In macrophages, miR-34a regulated M1 and M2 macrophage polarization as well as cholesterol efflux via liver X receptor å (LXRå) and Kruppel-like factor 4 (KLF4). Consistent with these findings, macrophage-selective or global ablation of miR-34a markedly inhibited the development of atherosclerosis in Ldlr-/-mice or Apoe-/-mice. Finally ...

Converting smooth muscle cells to macrophage-like cells with KLF4 …

WebAtherosclerosis, the leading cause of death, is a vascular disease of... WebApr 8, 2024 · The anti-inflammation and antifibrosis may be one of the mechanisms of KLF4 against atherosclerosis . However, KLF4 activated NF-κB signaling pathway and affected the release of pro-inflammatory ... pompe marlow 4380 800

Myeloid Krüppel-Like Factor 4 Deficiency Augments …

WebOct 3, 2024 · Conclusions: KLF4 transactivates Ch25h and LXR, thereby promoting the synergistic effects between ECs and macrophages to protect against atherosclerosis susceptibility. Keywords: atherosclerosis; cholesterol; endothelial cells; inflammation; … WebAtherosclerosis, the leading cause of death, is a vascular disease of... WebJul 1, 2024 · Nicotine injection with balloon overdilation induces atherosclerotic lesions by activating KLF4 expression. Atherosclerosis is a chronic inflammatory disease characterized by the narrowing of the ... pompei\u0027s state street sandwiches media pa

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate

Tenascin-X Mediates Flow-Induced Suppression of …

WebRationale for Study: MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein expression at post-transcriptional level. We hypothesized that a specific pool of endothelial miRNAs could be selectively regulated by flow conditions and WebMay 24, 2024 · The KLF4 gene is itself a CAD GWAS risk allele with the putative variant (rs944172) located ≈265 kb upstream of the KLF4 transcription start site. The nature of this variant is unclear; however, it overlaps a weak AP1 binding site with some evidence for … pompe lave vaisselle whirlpoolWebFeb 8, 2024 · KLF4 promotes phenotypic modulation into macrophage-like and Sca1-expressing mesenchymal-like VSMCs, while MSCs differentiate into VSMCs in vitro when exposed to TGFβ and PDGF-BB. VSMCs might also derive from ECs following EndMT driven by TGFβ signalling. shannon webb

"WebJan 1, 2024 · As a zinc finger domain-containing transcription factor, KLF4 involves in atherosclerosis development 27, 65. More importantly, it is reported that KLF4 is a critical regulator of macrophage polarization, and expression of KLF4 was robustly induced in M2 macrophages while markedly reduced in M1 macrophages 31. " - Klf4 atherosclerosis

Klf4 atherosclerosis

Frontiers C1q/TNF-Related Protein 9 Attenuates Atherosclerosis …

WebJan 1, 2024 · These results indicate that formononetin may regulate KLF4 expression during atherosclerosis development. Given the role of KLF4 and SRA in atherogenesis, we postulate that formononetin may be antiatherogenic, in part, through regulation of KLF4-SRA … WebFeb 1, 2024 · Concordantly, cardiac-specific Klf4–/– mice develop heart dysfunction with aging or pressure overload associated with reduced ATP production, increased reactive oxygen species production, and mitochondrial dysfunction.

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WebAtherosclerosis, the leading cause of death, is a vascular disease of... WebJul 17, 2024 · Taken together, our results suggest that most SMC phenotypes in advanced atherosclerotic lesions are conserved between humans and mice, and, taken with previous knowledge that SMC Klf4 is atheropromoting in mice and contains a human GWAS CAD …

WebFeb 13, 2024 · KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015; 21:628–637. doi: 10.1038/nm.3866 Crossref Medline Google Scholar; 13. Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, … WebDec 1, 2014 · Blockade of mir-92a restores Klf2 and Klf4 expression, reduces endothelial inflammation and monocyte infiltration, thereby limiting atherosclerosis. 19 Disturbed flow and other proatherogenic factors also downregulate the endothelial expression of negative guidance cues, particularly Netrin-1 and Semaphorin3A, while upregulating EphrinB2, and …

WebApr 21, 2024 · Laminar, but not disturbed flow, induces expression of the extracellular matrix protein TN-X (tenascin-X) in mouse and human endothelial cells through the transcription factor KLF4 (Krüppel-like factor … WebNov 26, 2024 · In this mechanism induced by oxidized low-density lipoprotein (oxLDL), the KLF4 factor suppresses the expression of VSMC genes (SM22α, ACTA2, MYH11) by binding to the G/C repressor element in the gene promoter and by inhibiting the binding of transcription factors to the CArG element mechanism, leading to phenotypic switching ( …

WebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many that regulate pro-inflammatory responses of SMCs.

WebDec 13, 2024 · KLF4 is a zinc-finger-containing transcription factor that plays a crucial role in maintaining cell senescence in response to cellular stress. Studies have shown that KLF4 typically upregulates p21 to promote cell growth arrest ( Chew et al., 2011 ). pompe karcher sp6WebKLF4 plays an important role in several vascular diseases where it was shown to regulate vascular inflammation by controlling macrophage polarization and plaque formation in atherosclerosis. It up-regulates Apolipoprotein E, which is an anti-atherosclerotic factor. It is also involved in the regulation of angiogenesis. pompe master pumps 1100wWebDec 5, 2024 · Our study indicates that KLF4 mediates the link between glycolytic switch and VSMCs phenotypic transitions, suggesting that a previously unrecognized KLF4-eEF1A2/circCTDP1-PFKFB3 axis plays... pompe mthWebOct 11, 2012 · In summary, our observations implicate myeloid KLF4 as a key regulator of experimental atherogenesis in mice. The fact that KLF4 has been shown to confer favorable anti-inflammatory effects in both the … pom pen cartridge fakeWebIntroduction. Atherosclerosis is a disease of chronic inflammation and is the leading cause of morbidity and mortality worldwide. There is general consensus that the majority of coronary syndromes are the result of rupture of unstable plaques and associated thrombotic events 1-3.Plaque instability has been associated with disruption of the fibrous cap, an … pompe marchisioWebJun 11, 2024 · In addition, a pivotal contribution of KLF4-dependent regulation of macrophage function to cardiovascular disease is exemplified by the observation that myeloid Klf4 deficiency augments vascular inflammation and atherosclerotic lesion formation in Apoe −/− mice . A surprising function of KLF4 in atherosclerosis was also … pomp englishWebJun 4, 2015 · KLF4 is also a crucial factor for the generation of induced pluripotent stem cells 9. It has also recently been shown that loss of Klf4 in endothelial cells (ECs) or myeloid cells results in... shannon webber