Itpr3
Web3 jul. 2024 · Oct 2015 - Apr 20245 years 7 months. Singapore. Scientific Highlights. • A team player in the precision oncology effort at GIS, helped to develop patient-derived cell-lines for phenotypic drug screens. • Led the development of models to study colorectal cancer metastasis using patient-derived cell-lines. • Led the development of ... WebPatients with head and neck squamous cell carcinoma are at increased risk of developing a second primary malignancy, which is associated with poor prognosis and early death. To help improve clinical outcome, we aimed to identify biomarkers for second primary malignancy risk prediction using the routinely obtained formalin-fixed paraffin-embedded …
Itpr3
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Web28 apr. 2024 · ITPR3 is a caffeine-sensitive inositol 1,4,5-triphosphate (IP3) receptor that releases calcium from the endoplasmic reticulum and enhanced metastatic colonization …
Web5 jun. 2014 · In this study, we examined tear secretion in mice lacking the inositol 1,4,5-trisphosphate receptor (IP 3 R) types 2 and 3 ( Itpr2−/−;Itpr3−/− double-knockout mice). We found that tear secretion in both the parasympathetic and sympathetic pathways was abolished in Itpr2−/−;Itpr3−/− mice. Intracellular Ca 2+ elevation in lacrimal ... Web25 nov. 2024 · As ITPR3 expression is a common event in HCC development (), the presence and distribution of this Ca 2+ channel was evaluated in HCC samples from different etiologies.ITPR3 staining of cholangiocytes was used as an internal positive control, as this liver cell type constitutively expresses ITPR3 ().There was greater ITPR3 labeling, …
Web11 feb. 2024 · ITPR3, as a ubiquitous endoplasmic reticulum calcium channel protein, was reported to be involved in the development and progression of various types of cancer. … Web1 jan. 2024 · Overexpression of ITPR3 also contributes to the pathogenesis of hepatocellular carcinoma (HCC) [81].Under normal conditions, ITPR2 makes up ∼80 % of the total pool of ITPRs in hepatocytes, whereas ∼20 % is ITPR1, and little to none is ITPR3 [22, 82].ITPR3 begins to become expressed in hepatocytes in conditions of chronic liver inflammation, …
Web1 apr. 2015 · Yamamoto-Hino et al. (1994) cloned cDNAs coding for human type 2 and type 3 inositol 1,4,5-triphosphate receptors. The complete nucleotide sequences for both receptors were determined. The human type 2 (ITPR2) and type 3 (ITPR3; 147267) receptors are 2,710 amino acids and 2,671 amino acids long, respectively, and have …
WebProbably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. polygon listWebDescription: Homo sapiens inositol 1,4,5-trisphosphate receptor type 3 (ITPR3), mRNA. (from RefSeq NM_002224) RefSeq Summary (NM_002224): This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the … polygon heist 1.0WebPROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA. ITPR3 INFORMATION. Proteini. Full gene name according to HGNC. Inositol 1,4,5 … bank transfer metamaskWeb11 feb. 2024 · ITPR3, which is also known as Type 3 inositol 1,4,5-trisphosphate receptor, is one of three highly homologous isoforms of ITPRs (inositol 1,4,5 trisphosphate … polygon pokemon typesWebAntibodies that detect ITPR3 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Immunoprecipitation, Immunocytochemistry and … polygon siskiu t7 xlWebthe inositol 1, 4, 5-trisphosphate receptor (itPr3) in human liver samples, liver cancer cells and mouse liver were combined with an evaluation of Dna methylation profiles of itPr3 promoter in Hcc and characterisation of the effects of itPr3 expression on cellular proliferation and apoptosis. the effects of de novo itPr3 expression polygon punks rarityWeb37343_at 3710 ITPR3 37393_at 3280 HRY 37403_at 301 ANXA1 37405_at 8991 SELENBP1 37409_at 6733 SRPK2 37695_at 9781 UBCE7IP4 37701_at 5997 RGS2 37716_at 4345 MOX2 37724_at 4609 MYC 37732_at 23429 RYBP 38035_at 9107 MTMR6 38042_at 2539 G6PD 38051_at 4118 MAL 38087_s_at 6275 S100A4 polygon mountain bike