Grwd1 and p21
WebGlutamate-rich WD repeat-containing protein 1 (GRWD1), as a novel CDT1-binding protein, plays a critical role in the initial stage of DNA replication. To date, few studies have shown that GRWD1 is a driving factor for lung cancer, bladder cancer, and colorectal cancer. However, no systematic pancancer analysis has been carried out. WebGRWD1 is a novel negative regulator of p53 and a potential oncogene, and its effects are mediated by the N‐terminal region of GRWD1, including the acidic domain. The ribosomal protein L11 (RPL11) binds and inhibits the MDM2 ubiquitin ligase, thereby promoting p53 stability. Thus, RPL11 acts as a tumor suppressor. Here, we show that GRWD1 …
Grwd1 and p21
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WebJun 1, 2005 · GRWD1 encodes a 446-amino-acid protein containing a glutamate-rich region followed by four WD repeats. The yeast homologue of GRWD1, Rrb1, ... including the … WebGRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we found that GRWD1 expression …
WebMar 29, 2024 · GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway. findings suggest a novel oncogenic function of GRWD1 as a transcriptional regulator of p53 and that GRWD1 might be an attractive therapeutic target and prognostic marker in cancer therapy; WebGRWD1 INFORMATION. Proteini. Full gene name according to HGNC. Glutamate rich WD repeat containing 1. Gene namei. Official gene symbol, which is typically a short form of …
WebMar 2, 2024 · Objective: GRWD1 (glutamate-rich WD40 repeat containing 1) is a multifunctional protein involved in multiple cellular regulatory pathways, particularly those associated with cell growth control. GRWD1 is represented as a potential oncogene in several cancers, however, the function and mechanism of GRWD1 in the development of … WebJan 1, 2024 · Europe PMC is an archive of life sciences journal literature.
WebDec 21, 2024 · Among them, GRWD1 regulates epigenetic active mark H3K4me3 by interacting with WDR5 and MLL2 and recruiting them to chromatin loci of specific genes in KSHV-transformed cells. Discover the world's ...
Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 classroom schematic minecraftWebAug 3, 2024 · GRWD1 also belongs to the family of DNA damage-binding protein 1 (DDB1)-interacting WD40 proteins, which function as candidate substrate receptors for Cul4–DDB1 ubiquitin ligases (note that there are Cul4a and Cul4b forms of Cul4 in mammals) (He et al., 2006; Higa et al., 2006).For example, Cdt2, a Cul4–DDB1-interacting WD40 protein, is a … classroom screen for kidsWebThe expression of downstream genes of the Notch signaling pathway Hes1, Hes5, Hey1, Hey2, p21, c-Myc, cyclin D1, human epidermal growth factor 2 receptor and NF-κB were … download siswebWebGRWD1 INFORMATION. Proteini. Full gene name according to HGNC. Glutamate rich WD repeat containing 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. GRWD1 (GRWD, RRB1, WDR28) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). classroom screen frWebJun 1, 2001 · Interacts with CDT1; origin binding of GRWD1 is dependent on CDT1 (PubMed:25990725). Interacts with CDC6; origin binding of GRWD1 is dependent on CDC6 (PubMed:25990725). Binds to histone H2A-H2B and H3-H4 complexes (PubMed:25990725). 2 publications. Protein-protein interaction databases. BioGRID. … download siswati bible for pcWebJan 1, 2024 · GRWD1 interacted with the p21 and MDM2 promoters, and these interactions required p53. By using the Human Cancer Genome Atlas database, we found that … classroom scholarclassroom school recycling bins