WebDec 6, 2024 · The emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae (GC) underline the need of “antibiotic-free” strategies for the control of gonorrhea. The aim of this study was to assess the anti-gonococcal activity of 14 vaginal Lactobacillus strains, belonging to different species (L. crispatus, L. gasseri, L. vaginalis), … WebNational Center for Biotechnology Information
Frontiers Implicating the Role of GILZ in Glucocorticoid …
WebApr 28, 2024 · MKP-1 is an important MAPK signal inhibitor that is induced by GCs and mediates GC inhibition of ERK, JNK, and p38 MAPK activities as well as cytokine production induced by pro-inflammatory stimuli, such as LPS or IL-1 (109–111). MIF has been shown to downregulate GC-induced leucine zipper (GILZ) expression through a … WebAug 7, 2024 · Biology. Frontiers in Immunology. Glucocorticoid-induced leucine zipper (GILZ) is a protein with multiple biological roles that is upregulated by glucocorticoids (GCs) in both immune and non-immune cells. Importantly, GCs are immunosuppressive primarily due to their regulation of cell signaling pathways that are crucial for immune system ... meaning of sustains
Glucocorticoids inhibit glucose transport and glutamate …
WebDec 9, 2009 · By pretreating with the GC inhibitor LY83583, significantly higher concentrations of SS were required to suppress the growth of MDA-MB-231 breast tumor cells as evidenced by almost a 2-fold increase in the IC 50 value (Fig. 2C, left). As a control, LY83583 was tested for its ability to affect the sensitivity of the MDA-MB-231 cells to … WebMar 26, 2024 · Introduction. Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer mortality worldwide. One million cases are diagnosed annually worldwide, with approximately 50% of these found in China 1, 2.Most patients present with inoperable advanced or metastatic disease that has a 5-year survival rate of … WebIntroducing specific sodium channel blockers into a tissue allows for the preferential binding of the blocker to sodium channels, which results in an ultimate inhibition of the flow of … meaning of sute